These comprise troponin subunits troponin T (TnT), troponin I (TnI), and troponin C (TnC) (Figure 1). Within each tropomyosin protein are complexes of heterotrimeric troponin. Tropomyosin is a long, coiled protein that spans most of the actin filament and is an important regulator of muscle contraction, preventing myosin adherence (and hence preventing contraction). Aggregates of sarcomeres assemble linearly into myofibers, and calcium flux causes contraction of the structure. The thick (myosin) and thin (actin) filaments within the sarcomere interlock, such that each thick filament is surrounded by six thin ones. High school biology teaches students that the basic structure of muscle contraction is the sarcomere, a repeating micrometer-sized unit that dictates the anatomy of both cardiac and skeletal striated muscle. For i-STAT test cartridge information and intended use, refer to individual product pages or the cartridge information (CTI/IFU) in the i-STAT Support area.Ībbott - A Leader in Rapid Point-of-Care Diagnostics.In order to place what we know about troponin T and I in context, it is worth reviewing the fundamentals of troponin expression and biological action. Check with your local representative for availability in specific markets. Not all products are available in all regions. GDPR Statement (last updated: May 2018) | California Transparency in Supply Chains Act | Declaration for California Compliance Law. Any person depicted in such photographs is a model. Photos displayed are for illustrative purposes only. Your use of this website and the information contained herein is subject to our Website Terms and Conditions and Privacy Policy: US Citizens | Non-US Citizens. The products and information contained herewith may not be accessible in all countries, and Abbott takes no responsibility for such information which may not comply with local country legal process, regulation, registration and usage. This website is governed by applicable U.S. No use of any Abbott trademark, trade name, or trade dress in this site may be made without the prior written authorization of Abbott, except to identify the product or services of the company. Unless otherwise specified, all product and service names appearing in this Internet site are trademarks owned by or licensed to Abbott, its subsidiaries or affiliates. Optional Advanced Quality Features and STAT Notes help integrate test results into your facility’s software to streamline information management. The i-STAT 1 can connect to multiple data management systems including Abbott Info HQ ® or AEGISPOC TM - to integrate seamlessly with your Laboratory Information System, Electronic Medical Records or both to help you manage test results, operators and devices. Testing and obtaining time-sensitive results at the patient’s side streamlines the testing process and eliminates process steps, handoffs and delays to help reduce errors, enable rapid decision-making, and optimize patient-care. Provides accurate results in approximately 2 minutes for most tests. Clear and comprehensive instructions help the operator through the testing process. Testing can be performed in 4 simple steps at the patient’s side with only 2 to 3 drops of whole blood. Each test cartridge has a unique combination of biosensors to suit a wide range of clinical needs. Single-use i-STAT test cartridges offer a broad menu of tests on a single, portable platform.
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